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Like the Chorein_N-domian-containing protein VPS13, which transfers phospholipids between the ER and other organelles (Kumar et al, 2018), ATG2 protein forms a long hydrophobic groove where the fatty acid chains of phospholipids can be accommodated, enabling ATG2 to transport phospholipids from the ER to phagophores for their expansion (Osawa et al, 2019

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This comprehensive diagram illustrates the regulation and multifaceted effects of growth hormone (GH) through the hypothalamic-pituitary axis, including negative feedback control