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Lowered response threshold and increased responsiveness to mechanical stimulation of cutaneous nociceptive fibers in streptozotocin-diabetic rat skin in vitro correlates of mechanical allodynia and hyperalgesia observed in the early stage of diabetes

They work best when combined with antimicrobial treatment, detox strategies, nutrition, lifestyle changes, and interventions targeting the root causes of Lyme and mold symptoms

Consequently, whilst it is clearly a key component in the diet and there may be potential for supplementation to have beneficial effects, evidence to support the administration of tryptophan above and beyond what can be consumed in a healthy diet is currently lacking and further investigation is required