This is a commonly referenced study from 1963 claiming a half-life of 5-6 days: nature.com/articles/198200a0 Although I would not cite it as an authority, the six-day half-life has also made it onto the B12 page in Wikipedia, seemingly unchallenged
Unexplained elevations above 1,000 pg/mL warrant further investigation, not panic, but not dismissal either
Specifically, analyzed were the affected brain areas (04), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), and hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) as follows (score 0 indicates no histopathologic change): score 1: small, patchy, complete, or incomplete infarcts (10% of the area affected)
That's what makes dermatological research such a fascinating field