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This cytochrome metabolizes some endogenous compounds (e.g., polyunsaturated fatty acids, steroid hormones), small-molecule xenobiotics (e.g., ethanol, carbon tetrachloride), and a relatively small number of drugs for which it is mostly a complementary pathway of metabolism

Six Phase I/II clinical trials enrolling approximately 900 participants confirmed an excellent safety profile with no serious adverse events attributed to the compound

J Clin Endocrinol Metab (2001) 86(3):11603