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Unless instructed by a health care provider, this injected site is not recommended because untrained injectors may damage the sciatic nerve

Indirect network meta-analyses rank retatrutide highly, but that is cross-trial inference, not a direct win

I would not recommend them if you: Are currently pregnant or breastfeeding Have a known active cancer diagnosis (especially hormone-sensitive cancers) Are on immunosuppressive therapy without coordination with your specialist Have a history of severe allergic reactions to peptide-based medications As with all treatments, personalized guidance matters

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