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Initial molecular docking results predicted ideal docked poses ( 9.346 to 5.795 kcal/mol) for tyrosinase with selected flavonoids

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In the case of alcohol the mechanism is well described: ethanol metabolism involving the CYP2E1 enzyme releases free radicals, and these reduce the level of reduced glutathione in the liver (Lieber, Drug Metabolism Reviews 2004, PMID 15554233)

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Keku T, Millikan R, Worley K, Winkel S, Eaton A, Biscocho L, Martin C, Sandler R

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