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Additional evidence suggests that the reducing reaction of NAC can replenish small molecule thiols and regulate the redox state, as well as facilitate cysteine recycling through the formation of cystine or mixed disulfides involving cysteine (Aldini et al., 2018)

Tsutsumi-Ishii Y, Nagaoka I: Modulation of human -defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production

Notably, the deletion of Slc7a11 (which encodes xCT) in animals results in viable offspring 15 , which suggests that tissues (and potentially tumours) can obtain cysteine from another origin