Los pptidos son esteroides
Dysfunction of the vasculature, endothelium, and coagulation Since persistent inflammation and immune cell activation is present in ME/CFS (305), vascular changes and endothelial damage (306, 307) will coexist due to the interplay between inflammation and vascular alterations
Papp K, Reich K, Leonardi CL, Kircik L, Chimenti S, Langley RG, Hu C, Stevens RM, Day RM, Gordon KB, Korman NJ, Griffiths CE (2015) Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)
Users have reported spontaneous erections and increased sexual desire as side effects, leading to off-label interest in its use for ED