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In neuronal tissue, it has been described that nicotine leads to increase in intracellular Ca 2+ in pre-synaptic terminals due to an increment on calcium conductance of nAChR subtypes, and indirectly via intracellular signalling cascades (Zhong et al., 2015)

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Here is a list of possible causes of scratching and itching in pets in random order: Atopy Drug reaction Flea allergy dermatitis Food allergy Lice Autoimmune disease Pyoderma Contact Dermatitis Viral infection Fungal infection (Malassezia) Psychogenic Mites Seborrhea Signalment Typically, atopy occurs in mature dogs between 1- 3 years of age, although it can occur earlier (Shar peis can get it as early as 3 months)

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