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Conceptual Origin: From Empirical Observation to Theoretical Framework In the 16th century, the Swiss physician Paracelsus established the philosophical foundation for dose-response relationships with his statement, The dose makes the poison ( Sola dosis facit venenum )

Nutrient malabsorption: Gut microbiome dysbiosis impairs the absorption of essential nutrients, including B vitamins (such as B 6 , B 12 , and folate) and trace minerals like zinc, which are vital for neuronal function and cognitive health

Prostate cancer was intimately linked to androgen and androgen receptor [3]

When the enzyme isn't there to recharge the glutathione, the levels of this master antioxidant naturally drop