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Meade RM, Fairlie DP, Mason JM (2019) Alpha-synuclein structure and Parkinsons diseaselessons and emerging principles

This results in IGF1-LR3 remaining in the bloodstream 120 times longer than IGF-1

The mechanism of actions in medical plants is broad, including regulating intestinal microbiota and permeability, upregulating both mRNA and protein expressions of claudin-1, lowering extracellular signal-regulated kinase activation in hepatocytes, suppressing MLCK-MLC phosphorylation signaling pathway, and protecting on IECs against LPS-insult [198]

Fifth, the dataset did not include APOE genotype information or detailed dementia subtype classification (e.g., Alzheimers disease versus vascular dementia), which may represent unmeasured confounders