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Blood 106, 25722579

Glutathione plays an important role in protecting cells from free radical damage and maintaining the bodys natural detoxification processes

2,3 The REDEFINE 1 trial found that when evaluating the treatment effect regardless of whether patients stayed on treatment, those treated with CagriSema achieved weight loss of 20.4% (from an average baseline body weight of 236 lb.) at 68 weeks versus 3.0% (from an average baseline body weight of 235 lb.) for the placebo group which was statistically significant

To determine whether the weight loss was due to the accumulation of trans -sulfuration pathway intermediates 12 , we provided Cse / mice with a diet lacking both methionine and cysteine and compared the effect to that of the no-Cys diet