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Silymarin constrains diacetyl-prompted oxidative stress and neuroinflammation in rats: involvements of Dyn/GDNF and MAPK signaling pathway

PMID: 31102632

In the study of OA, transcriptomic analysis has become an essential tool for understanding the changes in key genes and signaling pathways during joint degeneration and pathology

Further, a causeeffect relationship has been reported between genes coding for nitrogen metabolizing enzymes such as glutamate dehydrogenases (GDH EC 1.4.1.3), ornithine decarboxylases (ODC EC 4.1.1.17), and chitin biosynthetic enzymes such as chitin synthases (CHS EC 2.4.1.16)