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Key molecular features include the F23 Cagri residue anchoring the peptide at the receptor transmembrane (TM) bundle level and the micelle, an E14-R17 intramolecular salt bridge enhancing helical stability, and C-terminal P37 Cagri interaction with the receptor ECD

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Imaging studies often showed a hypervascular thyroid on ultrasound and increased uptake on scintigraphy, consistent with active Graves disease

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