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What the Research Suggests Clinical studies and pilot trials evaluating intralesional PRP for Peyronies disease have demonstrated: Favorable safety profiles Potential improvements in curvature and sexual function Reduced plaque density in some patients Some investigational protocols specifically include plaque needling prior to PRP injection , recognizing that mechanical disruption may enhance the effectiveness of regenerative therapies

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However, the therapeutic effects have only been confirmed in only been confirmed in small clinical studies, and larger clinical trials are required to investigate their potential benefits and mechanisms (136)

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