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Polycystic liver can be observed in the rat (Muff et al

[4] Conlon NJ

Moreover, many other factors are implicated in the development of classical GD

196 In the tumor environment, succinate could be produced and released by tumor cells, and via interacting with succinate receptor 1 to activate phosphoinositide-3-kinase/protein kinase B pathway and upregulate HIF-1, inducing macrophage polarization, and enhancing tumor cell metastasis