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Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle

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Oxidation of cysteine residues can result in a wide range of redox-based, post-translational modifications, including S-nitrosylation, S-glutathionylation and sulfinic acid, sulfenic acid and disulfide formation 22,23 , which can generate conformational changes in protein structure and subsequent modulation of protein activity 24