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Abbreviations VLCKDs: Very low-calorie ketogenic diets SIE: Italian Society of Endocrinology EASO: European Association for the Study of Obesity KDs: Ketogenic diets BMI: Body mass index sHypo: Subclinical hypothyroidism TSH: Thyroid-stimulating hormone fT3: Free triiodothyronine T4: Thyroxine TT4: Total T4 fT4: Free T4 kcal: Kilocalories LCD: Low-calorie diet L-T4: Levothyroxine TRH: Thyrotropin-releasing hormone TPO: Thyroid peroxidase GLUT4: Glucose transporter type 4 References Papers of particular interest, published recently, have been highlighted as: Of importance Of major importance Muscogiuri G, Barrea L, Laudisio D, Pugliese G, Salzano C, Savastano S, Colao A

It is a complex polymer formed by indole or phenolic compounds synthesized within melanosomes-specialized organelles in melanocytes (Li R