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CagriSema exceeded the additive effect of both compounds individually

Normal distributions were applied to all inputs, with the mean obtained from the previous optimisation procedure, and coefficient of variation of 180%

Synthetic AT may be divided into two main categories: (i) those that have been primarily developed and synthetized as AT and (ii) compounds that primarily act via different mechanisms of action, while their AT properties were discovered later, which may contribute to their biological activity (as observed for some clinically used drugs, e.g., 4-aminosalicylic acid with inflammatory bowel disease (IBD))

It also binds more strongly to opioid receptors than most other opioids