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The ultimate goal of future studies should be to combine CD4 + and CD8 + responses in vivo to activate DCs and T cells for a long period of time

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[73,74] Other peptides derived from histone proteins have shown similar effects and have been investigated as therapeutic candidates in SLE, [75, 76, 77] including the phosphorylated spliceosomal epitope peptide P140, which represses B cell differentiation and protects against murine lupus