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Leo R, Apolnio JD, Lee D, Figueiredo A, Tabori U, Castelo-Branco P (2018) Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

Before approving a new drug, the FDA typically requires companies to conduct a type of study called a randomized controlled trial, in which study participants are allocated by chance to groups that either receive the drug, or are administered a placebo

This makes it very reliable, but it also has some properties that make it quite annoying to use: it is quite unstable , especially when dissolved in water it oxidizes quickly and has a short shelf life