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Thus, while the PI3K signaling pathway appears to be a central player in mediating insulins effect in many cell types, other signaling pathways activated by insulin may act more in a tissue-specific manner in the up-regulation of GCLC expression and GSH level

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Figure S2B in Supplementary Material)

James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH, Cutler P, Bock K, Boris M, Bradstreet JJ, Baker SM, Gaylor DW: Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism