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That creates uncertainty in areas such as: long-term use beyond typical protocol durations rare side effects that require large sample sizes to detect interactions with complex medication regimens outcomes in special populations such as pregnancy, cancer history, or severe autoimmune disease The right response to uncertainty is not fear, and it is not blind confidence

Bradley encounters is that a normal physical automatically means someone is healthy

The pharmacodynamic concepts of maximum response and sensitivity determine the magnitude of the effect at a particular concentration (see E max and C 50 , Chapter 2