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Hence, the low levels of thiomethyl metabolites observed after APAP exposure are probably associated to the limited cytochrome P450 capabilities of in vitro models to generate NAPQI metabolites via CYP2E compared to in vivo hepatocytes

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Release the water gently Let the water run gently down the side of the vial

Randomization was conducted using an interactive web response system, assigning participants in a 6:1 ratio to one of several treatment arms: once-weekly subcutaneous Cagrilintide administered in doses of 0.3, 0.6, 1.2, 2.4, or 4.5 mg, once-daily liraglutide 3.0 mg, or a volume-matched placebo