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They found that microbial infections, such as SARS and H5N1 virus infections in the lungs, trigger NADPH-dependent ROS production, thereby generating oxidized phospholipids, such as oxidized 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine, to induce lung injury and cytokine production by lung macrophages via TLR4TRIF 80

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By normalizing or increasing the efficiency of glucose metabolism, thiamine decreases the degradation of amino acids as energy substrates and increases protein synthesis, which is essential for maintaining tight junctions and intestinal barrier integrity (194)