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a 2025 literature review identified limited clinical evidence, including a retrospective study of 12 patients with knee pain and a Phase I trial in healthy volunteers whose results were not submitted

The primary compounds in the formula are methionine, inositol, and choline: Methionine is an essential amino acid Inositol supports proper cell formation Choline is a water-soluble nutrient that supports liver function Together they metabolize fat cells and assist in the elimination of stored fat deposits in the liver and body, and may encourage fat reduction

Proton pump inhibitors and H2 receptor antagonists, commonly used for gastroesophageal reflux disease and peptic ulcer disease, may affect vitamin B12 status through multiple mechanisms

In the study conducted by Chang et al