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Figure 1 Structure and function of SLC7A11 System Xc- is composed of two subunits: the light chain functional subunit SLC7A11, also referred to as xCT, and the heavy chain structural subunit SLC3A2, also known as CD98 or 4F2hc ( In humans, the gene encoding SLC7A11 is situated on chromosome 4 and comprises 14 exons, resulting in a protein sequence of 502 amino acids