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Third, the APP/PS1 transgenic mouse model of Alzheimers disease used in Sun 2021 to test Dihexa in an amyloid-pathology model, with Morris water maze, neuroinflammatory cytokines, and PI3K/AKT pathway activation as primary readouts

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It incorporates key modifications, including 14E/17R mutations to stabilize an -helical segment via a salt bridge, multiple proline substitutions (25P, 28P, 29P) to reduce -sheet formation, and N-terminal C20 fatty diacid lipidation for reversible albumin binding (Kruse et al

This means that any drug microparticle suspension can only provide the fraction of drug that is soluble in aqueous solution in any delivered suspension