The peptide activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in a dose-dependent manner, leading to nuclear translocation and activation of transcription factors including c-Fos, c-Jun, and early growth response-1 (Egr-1) that drive expression of genes involved in cell growth, migration, and angiogenesis
Here are a few that people often say are more painful: Tetanus shots, which can cause more soreness because the vaccine is a bit thicker
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The discomfort is typically minimal and brief