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Receptor activation triggers intracellular calcium release through phospholipase C and inositol trisphosphate (IP3) signaling, which causes GH-containing secretory granules to fuse with the cell membrane and release their contents into the bloodstream

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A meta-analysis of 11 studies in a total of 705 patients with chronic liver disease (seven different types, and one study only in patients with NASH) showed that SAMe improved AST and total bilirubin levels but not ALT levels [53]