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Peptides that act on the HPG axis include those that stimulate gonadotropin release indirectly via growth hormone or kisspeptin-modulating effects

For example, the treatment with acetyl-l-carnitine induced haeme oxygenase enzyme in rat astrocytes in a dose- and time-dependent fashion, heat shock protein 60 upregulation, and increased expression of the nuclear factor erythroid 2-related factor 2 transcription factor, a master regulator of antioxidant proteins [18]

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There may be other explanations why an effect could not be detected, such as a low sensitivity of the assessment method