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In the context of ovarian aging, it activates SIRT1-dependent pathways, which are critical for maintaining genomic stability, mitochondrial efficiency, and cellular survival ( in vitro and may mitigate ovarian dysfunction in reproductive disorders such as PCOS and endometriosis ( Although dietary-derived antioxidants, particularly polyphenols, demonstrate robust antioxidant and anti-inflammatory effects in preclinical models, their clinical translation is constrained by significant pharmacokinetic limitations

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The dose of NAC was chosen according to our published studies ( gpx1 / + NAC group compared with the peroxynitrite + gpx1 / group (Figure 6B)