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2 Molecular mechanisms of ferroptosis links to periodontitis Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation, characterized by dysregulated iron metabolism, accumulation of lipid peroxides, and impaired antioxidant defense

Lactylation contributes to these processes: in the rat cerebral ischemia models, lymphocyte cytosolic protein 1 (LCP1) lactylation increases significantly, and inhibiting glycolysis reduces LCP1 lactylation, promotes its degradation, and alleviates infarct progression (Zhang W

doi: 10.1007/978-3-319-95354-0_4 18 de BangT