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In a murine model of systemic infection, the combination of ibuprofen, and fluconazole can potentiate the antifungal activity of fluconazole by decreasing the MIC of fluconazole from 64 to 2 g/ml and reduce the fungal burden and morbidity in fluconazole resistant strains (Pina-Vaz et al., C

The reasons cited by the FDA included concerns about immunogenicity, peptide impurity characterization challenges, and the lack of adequate safety data from human clinical trials

Thiel mentioned the news outlet Gawker , which had recently outed him as gay