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This research primarily focused on assessing changes in substance P, beta-endorphin, and corticosterone levels, which are critical in understanding the stress response and potential modulatory impacts of DSIP

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The REDEFINE protocol escalated the dose over 16 weeks (0.25 0.5 1.0 1.7 2.4 mg), so the full pharmacologic dose was not reached until roughly week 17

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Diamond, L., et al

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