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Description

In zygotes formed by fertilizing normal eggs with sperm from hyperglycemic mice, insufficient TET3-mediated demethylation disrupted epigenetic reprogramming of sperm DNA, leading to hypermethylation of insulin secretion-related genes like Gck in the progenys pancreas

This paper endeavors to explore Elamipretide's biochemical basis and its potential as a therapeutic agent in various diseases linked to mitochondrial impairment