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A change in the function of nAChRs will influence the release and activity of other neurotransmitters whose release is controlled by these receptors including glutamate, dopamine, serotonin, glycine, and g aminobutyric acid (GABA) (Livingstone and Wonnacott, 2009)

These interactions will allow for discussion about how NAM data can be used to answer regulatory questions and foster further optimization of testing approaches to meet regulatory needs and best predict human health effects

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