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In the context of PD, several nutraceuticals such as polyphenols (e.g., curcumin, resveratrol), vitamins D and E, omega-3 fatty acids, flavonoids, and coenzyme Q10 have been studied for their antioxidant, anti-inflammatory, and mitochondrial-supportive properties

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The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis (Iorga et al., 2017)