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Selective DNAzyme-mediated cleavage of achr mutant transcripts by targeting the mutation site or through mismatches in the binding arm

Importantly, this does NOT make GHK-Cu FDA-approved, but it does signal continued movement in the peptide discussion ahead of upcoming PCAC meetings.

The publication reported the estimated mean percent change in body weight from baseline to week 68 for each arm, with the combination arm showing a substantially larger estimated reduction than placebo, and the cagrilintide-alone arm showing an intermediate reduction

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