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355), who was awarded a prize by this leading medical journal for his essay on tobacco smoking says: The first thing to bear in mind is that considering the large amount of tobacco used very little harm results, and care should be taken not to incriminate tobacco when the troubles under observation may be due to other causes. Secondly, among the investigators themselves who have made impartial inquiries about the effects of tobacco, there is sometimes a wide difference of opinion in the interpretation of results and in the relation of cause and effect