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Sever et al., 2019), thus avoiding and directly counteracting VEGF tumorigenesis (Radeljak et al., 2004)

Long-term benefits, however, need further studies

CEMIP, identified as an oncogene, enhances the stability and nuclear accumulation of c-Myc by inhibiting the ubiquitination of this proto-oncogene

Subsequent analysis of morphine-induced constipation in VgluT2-Cre mice injected with AAV-DIO-shMOR-EGFP revealed that PVN Glu -specific MOR knockdown resulted in significantly higher fecal output and fecal water contents, as well as significantly higher transit rates and motility in small intestine of morphine-treated mice compared to that of corresponding AAV-DIO-EGFP control animals (Fig