Several studies have shown that glutathione related enzymes like GSH S-transferase (GST) and GSSG reductase isoforms are not uniformly distributed in nuclei and cytoplasm [15]
Curcumin inhibited IL-6-induced proliferation, migration, and invasiveness of human small cell lung cancer (SCLC) cells by reducing JAK/STAT3 phosphorylation (i.e., activation) and downstream genes coding for cyclin B1, survivin, Bcl-X L , MMPs, intercellular adhesion molecule 1 (ICAM-1), and vascular endothelial growth factor (VEGF) (30)
Sikiric et al., 2018), it should be noted that Roberts cytoprotection generally holds a defensive response against direct injuries
[] Isoflavones can modify hormonal metabolism as well as other cellular mechanisms, such as the metabolism of intracellular enzymes, angiogenesis, cell proliferation, protein synthesis, and growth factor action