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This idea that nicotine can treat long COVID originates from an early observation which led to a hypothesis

Most participants (59.6%) were female, with similar proportions attending middle (53.8%) or high school (46.2%)

Comparison of serum and salivary cotinine measurements by a sensitive high-performance liquid chromatography-tandem mass spectrometry method as an indicator of exposure to tobacco smoke among smokers and nonsmokers

A separate analysis of a smaller subgroup of these adults who had never smoked tobacco cigarettes or used nicotine e-cigarettes also found a significant association between cannabis use and an increase in the combined odds of coronary heart disease, heart attack and stroke