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Through a process catalyzed by the enzyme Glutathione S-Transferase (GST) , glutathione physically attaches (conjugates) itself to these dangerous electrophilic xenobiotics and intermediate metabolites

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This reaction not only converts toxic oxidants into harmless substances (such as water) but also creates conditions for the subsequent reduction process by storing electrons in disulfide bonds

Behav Pharmacol 30(2 and 3-Spec Issue):163-186 Abdullahi W, Tripathi D, Ronaldson PT (2018) Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection