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NNMT is upregulated in obesity and cancer cachexia, and NNMT knockdown in mice protects against diet-induced obesity [2]

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In cases where the MIE is unknown or undefined, the earliest known KE in the chain (i.e., furthest upstream) should be used in lieu of the MIE and it should be made clear that the stated event is a KE and not the MIE

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