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Lastly, they propose that tirzepatide causes a thermogenic-like amino acid profile in BAT, which could explain why obese IR mice have lower systemic BCAA levels [82]

Intramuscular injection, by contrast, deposits peptide 1540mm deep (depending on needle length and injection site), requiring the compound to enter venous return, circulate systemically, and then diffuse back out of dermal capillaries to reach fibroblasts

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