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11), recent X-ray crystallography and cryo-EM data revealed that GSH binds the ATD of GLR3.4 30 , another GLR protein with high sequence similarity to GLR3.3, reinforcing that GSH might bind the ATD domain of GLR3.3 for activation of ion channel

Apical membrane localized NHE3 (Na + /H + -exchanger 3: encoded by the SLC9A3 gene) and V-ATPase (H + -ATPase) efflux H + into the tubular lumen in order to titrate HCO 3 present in the glomerular filtrate

Via UBA, P63 containing the LIR or GIM structure domain attaches to ubiquitinated protein aggregates, mitochondria, etc., and the LIR or GIM structural domain binds to LC3 or GABARAP on the autophagy membrane and then forms autophagosomes

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