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Of note is also that the supplementation with folic acid at doses higher than 1000 g/d was negatively associated with global verbal scores in children (Reference Valera-Gran, Navarrete-Muoz and Garcia de la Hera121)

Plant J 27(1):6778

To this end, we propose strategies such as advancing clinical trials and further exploring large animal models, which will help bridge the gap between preclinical findings and human therapeutic applications