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Robust, head-to-head studies are needed to clarify the therapeutic potential and mechanistic diversity of these compounds before their clinical application in DOR management can be meaningfully assessed

doi: 10.1002/bies.080137 76 ColoffJLMurphyJPBraunCRHarrisISSheltonLMKamiKet al

In some embodiments, one substantially purified HGF mimic is present in a composition

This hyper ECD motion was propagated to the receptor TMD, with motions within TMs 3 and 7, creating a wider TM pocket that also influences the positioning of the N-terminus of the Cagri peptide (Fig