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We speculate the controversial effect of NF-B pathway activation on inner ear cells, i.e., protecting or damaging cells, might rely on the cell and stimuli types

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doi: 10.1002/pmic.200900393 [DOI] [PMC free article] [PubMed] [Google Scholar] 343

Likewise, due to the large presence in human fetuses and adult tissues (in situ hybridization and immunostaining) [14], the concept holds a regulatory physiologic role in bodily functions [14], also based on similar beneficial effects in other species (i.e., birds [73] and insects [74,75,76])